Acetaminophen/Hydrocodone is a drug combination used to treat back pain; pain; rheumatoid arthritis; cough, and many other conditions. It is indicated for the management of pain severe enough to require opioid analgesic and for which alternative treatments are inadequate.

This pill belongs to the drug class narcotic analgesic combinations and is manufactured by Mallinckrodt Pharmaceuticals. Narcotic analgesics are also called opiates, narcotics or opioid analgesic. It contains one or more other analgesic such as acetaminophen. Acetaminophen is a pain reliever and a fever reducer at the same time which increases effects of hydrocodone, while the latter belongs to a group of narcotic drugs to relieve pain. This combination is more effective than either drug alone. Both drugs last for a similar length of time in the body which makes them appropriate to be given together.

Acetaminophen/Hydrocodone is effective at relieving pain but may however cause dependence and possibility of liver toxicity with too much use of acetaminophen.


 Misuse, Addiction, and Abuse

This medicine should only be taken by the person to whom it was prescribed for. This should never be given to another person especially to those with history of alcohol or drug abuse. Store in a place where others cannot get to it.

Respiratory Depression

Breathing problems may develop when starting this medicine or when the dose is increased. Recognize the signs and immediately inform the doctor if this happens.

Accidental Ingestion

This medicine should be disposed of properly to avoid accidental ingestion by children which may cause unwanted side effects or even death.

Interaction with other medicines (MAOI, Benzodiazepines, CNS Depressants)

Use of this drug combination with other medicines and alcohol may cause fatal addictive effects or unwanted side effects. Inform the doctor if you are taking other medicines or before undergoing surgery, dental extraction, and other treatments.

Serotonin Syndrome

Signs include: agitation or restlessness, confusion, rapid heart rate and high blood pressure, dilated pupils, loss of muscle coordination or twitching muscles, muscle rigidity, heavy sweating, diarrhea, headache, shivering, and goose bumps. Report to your doctor if you have these symptoms or if you feel anything unusual while taking this medication.

Side Effects

Constipation, nausea, sleepiness, vomiting, tiredness, headache, dizziness, and abdominal pain may occur. Inform the doctor with worsening symptoms.

Get emergency help if you have trouble breathing, shortness of breath, fast heartbeat, chest pain, swelling of your face, tongue, or throat, extreme drowsiness, light-headedness when changing positions, feeling faint, agitation, high body temperature, trouble walking, stiff muscles, or mental changes such as confusion.

Some other side effects may not be listed. Discuss with your doctor the risks and benefits of taking this medication or immediately call emergency services with severe or allergic symptoms.



  • This medicine is available in oral and liquid form and cost-saving generic versions.
  • Do not change your dose without doctor’s advice. Take exactly as prescribed.
  • Inform your doctor if the pain doesn’t go away with the dose you are taking or if you feel you have become addicted to this medicine.
  • Do not take more than your prescribed dose. If you miss a dose, take your next dose at your usual time.
  • Immediately call the doctor in case of an overdose (symptoms include extreme drowsiness, sweating, pinpoint pupils, nausea, vomiting, dark urine, jaundice (yellowing of the skin or eyes), confusion, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing).


Acetaminophen/hydrocodone may be harmful to the unborn child and may cause breathing problems or withdrawal symptoms in newborns. Inform your doctor if you are pregnant or planning to get pregnant or if you feel you are pregnant.


This medicine passes through breast milk and may harm the nursing infant. Do not use this medication without first informing your doctor.


Older adults are more sensitive to the effects of this medicine. Caution with use to avoid accident or falls.

Driving or Operating Machinery

Avoid driving or operating machinery or doing activities that involve risk until you know how this medicine affects you.


Drink 6 to 8 glasses of full water to prevent constipation and increase fiber in diet. Avoid use of stool softeners or laxatives without first informing your doctor.

Disposal of Unused Medicine

Keep out of the reach of children and pets. Flush unused tablets or dispose of properly.


Store acetaminophen and hydrocodone at room temperature away from moisture and heat.



This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

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